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It is well recognized that organ transplantation, with its associated immunosuppressive therapy, is complicated by an increased incidence of certain cancer. Among them post-transplant lymphoproliferative disorder is the second most common malignancy after skin cancer and often these syndrome are associated with serological evidence of EBV infection- We report 2 cases of malignant lymphoma in renal transplant patients within the first 6 months. Case 1. A 52-year-old-male with ESRD recieved a living related donor´ renal transplant and he was given OK-T3 for acute graft rejection. Then the graft function was improved and he did well postoperatively. Five months after transplantation, a huge sized mass(about 12 x 6 cm) on left submandibular area was developed and open biopsy showed diffuse B-cell lymphoma. EBV anti-VCA Ig G was positive(1:320) and in situ hydridization for EBV showed strong positive. He recieved MACOP-B chemothrapy, radia tion(total 6,480 rad) and acyclovir therapy, resulting partial remission. The last serum Cr was 1.1 mg/dl. Case 2. A 37-year-old-female with ESRD recieved a living non-related donor renal transplant. She did well postoperatively, but suddenly developed lower abdominal pain. On explolative laparation, about 5 x 4 x 3 cm sized irregular nodular mass was noted at mesenteric area of mid-jejunum and invaded jejunum was perforated. Diffuse large cell cleaved lymphoma, B-cell type, was confirmed on tissue pathology. EBV anti-VCA Ig G was positive(1:80) and in situ hybridization for EBV showed positive. After MACOP-B chemotherapy, she died due to leukopenia and sepsis
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